Chromosome-scale assembly of the yellow mealworm genome

Author:

Eleftheriou EvangeliaORCID,Aury Jean-Marc,Vacherie Benoît,Istace Benjamin,Belser CarolineORCID,Noel Benjamin,Moret Yannick,Rigaud ThierryORCID,Berro Fabrice,Gasparian Sona,Labadie-Bretheau Karine,Lefebvre Thomas,Madoui Mohammed-Amin

Abstract

Background: The yellow mealworm beetle, Tenebrio molitor, is a promising alternative protein source for animal and human nutrition and its farming involves relatively low environmental costs. For these reasons, its industrial scale production started this century. However, to optimize and breed sustainable new T. molitor lines, the access to its genome remains essential. Methods: By combining Oxford Nanopore and Illumina Hi-C data, we constructed a high-quality chromosome-scale assembly of T. molitor. Then, we combined RNA-seq data and available coleoptera proteomes for gene prediction with GMOVE. Results: We produced a high-quality genome with a N50 = 21.9Mb with a completeness of 99.5% and predicted 21,435 genes with a median size of 1,780 bp. Gene orthology between T. molitor and Tribolium castaneum showed a highly conserved synteny between the two coleoptera and paralogs search revealed an expansion of histones in the T. molitor genome. Conclusions: The present genome will greatly help fundamental and applied research such as genetic breeding and will contribute to the sustainable production of the yellow mealworm.

Funder

Horizon 2020 Framework Programme

Publisher

F1000 Research Ltd

Subject

Ocean Engineering,Safety, Risk, Reliability and Quality

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