Management of Minor ABO Incompatibility in Allogeneic Stem Cell Transplant by Plasma Reduction: Case Report from A Tertiary Care Private Hospital in Dhaka

Abstract

Human Leukocyte Antigen (HLA) matching plays a crucial role in allogeneic SCT outcome and remains the single most important factor for donor selection.  ABO blood group barrier is often crossed between patient and donor. ABO incompatibility may cause acute haemolysis due to transfer of high titter donor isohaemagglutinins contained in the graft or in paediatric patients with small blood volume. To overcome this obstacle, some amount of plasma present in progenitor cell product can be reduced. Plasma reduction can be done in many ways. For a financial constrain set up, we did the plasma reduction manually to overcome the complications and cost. Here we are presenting a case report from Bangladesh.