Report of the National Immunoglobulin Replacement Expert Committee: algorithm for diagnosis of immunodeficiency requiring antibody replacement therapy-Reference-Cited by-同舟云学术

Report of the National Immunoglobulin Replacement Expert Committee: algorithm for diagnosis of immunodeficiency requiring antibody replacement therapy

Published:2019-03-01 Issue:1 Volume:6 Page:31-33
ISSN:2292-5937
Container-title:LymphoSign Journal
language:en
Short-container-title:LymphoSign Journal

Author:

Betschel Stephen¹,Brager Rae²,Haynes Alison³,Issekutz Thomas⁴,Kim Vy Hong-Diep⁵,Mazer Bruce⁶,McCusker Christine⁶,Roifman Chaim M.⁵⁷,Rubin Tamar⁸,Sussman Gordon⁹,Turvey Stuart¹⁰,Waserman Susan¹¹

Affiliation:

1. Division of Clinical Immunology and Allergy, St. Michael’s Hospital, University of Toronto, Toronto, ON

2. Department of Pediatrics, McMaster Children’s Hospital, Hamilton, ON

3. Department of Pediatrics, The Janeway Children’s Hospital, Memorial University of Newfoundland, St. John’s, NL

4. Division of Immunology, IWK Health Centre, Dalhousie University, Halifax, NS

5. Division of Immunology and Allergy, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, ON

6. Division of Pediatric Allergy and Immunology, Department of Pediatrics, Montreal Children’s Hospital, McGill University Health Center, Montreal, QC

7. Canadian Centre for Primary Immunodeficiency, The Hospital for Sick Children, Toronto, ON

8. Pediatric Clinical Immunology and Allergy, University of Manitoba, Winnipeg, MB

9. Clinical Immunology and Allergy, Faculty of Medicine, University of Toronto, Toronto, ON

10. Division of Clinical Immunology and Allergy, Department of Pediatrics, BC Children’s Hospital, University of British Columbia, Vancouver, BC

11. Division of Clinical Immunology and Allergy, McMaster University, Hamilton, ON

Abstract

Immunoglobulin replacement therapy is a mainstay in the treatment of immune deficiencies characterized by antibody failure. Whether the cause is primary or secondary, affected patients frequently present with a history recurrent and complicated infections of the upper and (or) lower respiratory tract. Such replacement therapy has been available since the 1980s, although treatment modalities have since been refined to provide improved protection against infections resulting in reduced morbidity and mortality. Here, we describe an algorithm for diagnosing patients with suspected primary or secondary immunodeficiency, including assessment of clinical, laboratory, and genetic information, when considering initiating immunoglobulin replacement. The increasing availability of molecular genetic techniques will likely result in decreased diagnostic delay for these patients. Statement of novelty: We describe here an algorithm for diagnosing patients with immunodeficiency requiring immunoglobulin replacement therapy.

Publisher

LymphoSign Journal Limited Partnership

Subject

General Earth and Planetary Sciences,General Environmental Science

Link

http://lymphosign.com/doi/pdf/10.14785/lymphosign-2019-0003

Reference3 articles.

1. Infection outcomes in patients with common variable immunodeficiency disorders: Relationship to immunoglobulin therapy over 22 years

2. Primary Immunodeficiency Diseases: an Update on the Classification from the International Union of Immunological Societies Expert Committee for Primary Immunodeficiency 2015

3. HIGH-DOSE VERSUS LOW-DOSE INTRAVENOUS IMMUNOGLOBULIN IN HYPOGAMMAGLOBULINAEMIA AND CHRONIC LUNG DISEASE

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. COVID-19 post-vaccination recommendations for primary immunodeficiency;LymphoSign Journal;2021-09-01