Affiliation:
1. Department of Immunology, Complutense University School of Medicine, and Hospital 12 de Octubre Health Research Institute, Madrid, Spain.
Abstract
Immunodeficiencies of most T-cell receptor (TCR) components (TCRID) have been reported in almost 40 patients worldwide who have also, at times, shown signs of autoimmunity. We updated their clinical, immunological, and molecular features with an emphasis on practical diagnosis, as the range of the disorder grows in complexity with new partial defects. Cellular and animal models are also reviewed and in some cases reveal their limitations for predicting TCRID immunopathology.
Publisher
LymphoSign Journal Limited Partnership
Subject
General Earth and Planetary Sciences,General Environmental Science
Cited by
8 articles.
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