Affiliation:
1. Ludwig Maximilian University of Munich
Abstract
Abstract
Assembling hybrid substrates with nanometer-scale precision and molecular addressability enables advances in such distant fields as material research and biosensing. As such, the combination of lithographic methods with 2D DNA origami self-assembly has led, among others, to the development of photonic crystal cavity arrays and the exploration of sensing nanoarrays where molecular devices are patterned on the sub-micron scale. Here we extend this concept to the third dimension through mounting 3D DNA origami onto nano-patterned substrates followed by silicification to provide mechanical and chemical stability. Our versatile and scalable method relying on self-assembly at ambient temperatures offers the potential to 3D-position any inorganic and organic components that are compatible with DNA architectures. This way, complex and 3D-patterend surfaces designed on the molecular level while reaching macroscopic dimensions could supersede energy-intensive manufacturing steps in substrate processing.
Publisher
Research Square Platform LLC