Affiliation:
1. Fukui University of Technology
2. Osaka University
3. Tokyo University of Agriculture
4. Nagahama Institute of Bio-Science and Technology
Abstract
Abstract
Neurons are potential building blocks for implementing self-modifying and autonomous functions in robots. Cerebral organoids (COs) can partially reproduce the tissue morphology and cellular diversity of the brain and are suitable for implementing more complex self-modifying and autonomous functions. In this study, we assembled a bio-robot by connecting the CO to a functional muscle cell actuator (MCA). Immunofluorescence staining showed that the CO and MCA were extensively connected via axons. However, no significant changes were observed in the autonomic contraction of the MCA. Conversely, inhibition of the connection between the CO and MCA, which was blocked by a curare, resulted in a significant relaxation of the MCA. This result suggests that the CO controls the balance of the contraction force of the individual myotubes in the MCA, thus maintaining the shape of the MCA. The conclusion from this research could be a basis for an effective strategy for constructing a bio-robot with self-modifying and spontaneous functions using CO.
Publisher
Research Square Platform LLC
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