Pigment production by identified Pseudofusicoccum adansoniae: extract production, Cytotoxicity activity and diketopiperazines identified

Author:

Alves Bianca V. B.1,Borges Letícia J.1,Hanna Samira A.1,Soares Milena B. P.2,Bezerra Daniel P.2,Moreira Laysa Lanes Pereira Ferreira3,Borges Warley S.3,Portela Ricardo Wagner Dias1,Fernandez Clara Couto1,Umsza-Guez Marcelo A.1

Affiliation:

1. Federal University of Bahia

2. Gonçalo Moniz Institute, Oswaldo Cruz Foundation (IGM-FIOCRUZ/BA)

3. Federal University of Espírito Santo

Abstract

Abstract

This study aimed to molecularly identify an isolated fungus that produces a burgundy pigment, and to verify the influence of the type of light on the growth of the fungus and on the production of the pigment in submerged fermentation. In addition, a cytotoxicity assay was performed with HepG2, SCC4, BJ and MRC-5 cells, and the identification of the secondary metabolites produced by the fungus was performed by NMR. The isolated fungus was identified as Pseudofusicoccum adansoniae, which demonstrated better growth and pigment production under yellow light. The extract produced did not show cytotoxicity. Among the isolated compounds, cyclo(L-Pro-L-Val) and cyclo(L-Leu-L-Pro) (Diketopiperazines) have already been described in food and are produced by different organisms, presenting several beneficial biological activities. The identified fungus is a promising producer of biopigments, whose crude extract does not show cytotoxicity. The isolated compounds exhibit interesting biological activities in the food area, such as antibacterial, antifungal and antioxidant actions, making it a viable option for application in food as a natural pigment.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3