Guinea Pig Herpes like Virus is a Gamma Herpesvirus

Author:

Stanfield Brent A.1,Ruiz Emmanuelle1,Choulgenko Vladimir N.1,Kousoulas Konstantin G.1

Affiliation:

1. Louisiana State University School of Veterinary Medicine

Abstract

Abstract Guinea Pig Herpes-Like Virus (GPHLV) is a virus isolated from leukemic guinea pigs with herpes virus-like morphology described by Hsiung and Kaplow in 1969. GPHLV transformed embryonic cells from Syrian hamsters or rats, which were tumorigenic in adult animals. Herein, we present the genomic sequence of GPHLV strain LK40 as a reference for future molecular analysis. GPHLV has a broad host tropism and replicates efficiently in Guinea pig, Cat, and Green African-derived cell lines. GPHLV has a GC content of 35.45%. The genome is predicted to encode at least 75 open reading frames (ORFs) with 84% (63 ORFs) sharing homology to human Kaposi Sarcoma Associated Herpes Virus (KSHV). Importantly, GPHLV encodes homologues of the KSHV oncogenes, the latency associated nuclear antigen (LANA, ORF73) and viral cyclin (v-cyclin, ORF72) exhibiting 17.1% and 34.3% amino acid similarity, respectively. GPHLV is a Rhadinovirus of Cavia porcellus, and we propose the formal name of Caviid gamma herpesvirus 1 (CaGHV-1). GPHLV can be a novel small animal model of Rhadinovirus pathogenesis with broad host tropism.

Publisher

Research Square Platform LLC

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