Effect of Hesperidin on blood pressure and lipid profile: A systematic review and meta-analysis of randomized controlled trials

Abstract

Abstract Background The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta-analysis published on this topic in 2019. However, considering the recently published clinical studies there is a scope for performing a systematic review and meta-analysis on the cardioprotective effect of hesperidin. This systematic review and meta-analysis were performed to determine the beneficial effect of hesperidin in alleviating alterations in cardiovascular parameters based on available clinical studies. Methods The literature search was performed using online databases such as PubMed and Google Scholar. The search was mainly focused on the role of hesperidin in various cardiovascular disorders. Results Based on the inclusion and exclusion criteria 9 clinical studies involving 2414 subjects were included. The meta-analysis revealed that the hesperidin has significantly reduced the systolic blood pressure (Inverse variance (I.V): -0.86 (-1.53 to -0.18) at 95% CI, p = 0.01, I2 = 100%) and total triglycerides (IV: -0.21 (-0.40 to -0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the diastolic blood pressure (IV: 0.52 (-1.78 to 2.83) at 95% CI, p = 0.06, I2 = 100%), HDL (IV: 0.04 (-0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%), LDL (IV: -0.10 (-0.66 to 0.45) at 95% CI, p = 0.72, I2 = 85%), and total cholesterol (TC) (IV: 0.18 (-0.79 to 0.44) at 95% CI, p = 0.57, I2 = 88%) compared with the placebo/control. Conclusion The outcomes of the meta-analysis suggest that hesperidin administration could benefit patients with cardiovascular diseases by reducing systolic blood pressure and total triglycerides.