Affiliation:
1. Shivaji University
2. D.Y Patil Education Society Deemed University
Abstract
Abstract
A novel nano-magnetite supported N-heterocyclic carbene-gold
complex with pendant ferrocenyl group has been prepared by using a
multi-step procedure. The complex displayed significantly higher
anticancer activity against the MCF-7 breast cancer cell line with
IC50 = 32.38 µg/mL as compared with standard drug 5-fluorouracil
(IC50 = 25.29 µg/mL) in the MTT assay. The in-ovo antiangiogenic
activity of the complex using chicken chorioallantoic membrane
assay showed significant decrease in secondary blood vessels
indicating that it is efficient angiogenesis inhibitor. The
hyperthermia studies of the complex revealed a significant specific
absorption rate (SAR) value of 246.974 Wg-1 with therapeutic
temperature of 46.8 oC.
Publisher
Research Square Platform LLC
Reference33 articles.
1. S.M. Mousavi-Kouhi, A. Beyk-Khormizi, V. Mohammadzadeh, M. Ashna, A. Es-haghi, M. Mashreghi, V. Hashemzadeh, H. Mozafarri, M. Nadaf, M.E. Taghavizadeh Yazdi, Res. Chem. Intermed. 48(1),167–178 (2022).
2. M.F. Ahmed, A. AA. Hashim, Res. Chem. Intermed. 42, 1777–1789 (2016).
3. M. Yusefi, K. Shameli, Z. Hedayatnasab, S. Y. Teow, U. N. Ismail, C. A. Azlan, R. Rasit Ali, Res. Chem. Intermed. 47(5), 1789–1808 (2021).
4. S. V. Deo, S. Ray, G. K. Rath, N. K. Shukla, M. Kar, S. Asthana, V. Raina, Indian J. Cancer 41, 8 (2004).
5. S. Fulaz, C. Scachetti, L. Tasic, RSC advances 11, 4701–4712 (2021).
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