Association between gut microbiota and psoriasis: a bidirectional two-sample Mendelian randomization study

Abstract

Abstract Background: Research has found that the composition of gut microbiota is related to psoriasis and its subtypes. However, the causal effect of gut microbiota on psoriasis is still unclear. Methods: A two sample Mendelian randomization randomized study was conducted using the aggregated statistical data of intestinal microbiota in the meta-analysis of the largest available genome-wide association studies conducted by the MiBioGen Alliance. The summary statistical data for psoriasis, arthropathic psoriasis, and psoriasis vulgaris are from the FinnGen Alliance R7 release. Reverse variance weighting, maximum likelihood, MR Egger, weighted median, weighted model, MR-PRESSO, and cML MA were used to examine the causal relationship between gut microbiota and psoriasis, arthropathic psoriasis, and psoriasis vulgaris. In the forward Mendelian randomization randomization analysis, reverse Gregor Mendel randomization analysis was performed on bacteria found to have causal relationships with psoriasis, arthropathic psoriasis and psoriasis vulgaris. Cochran's Q statistics are used to quantify the heterogeneity of Instrumental variables estimation. Results: A higher genetically predicted abundance Odoribacter was associated with a reduced risk of psoriasis. While a higher genetically predicted abundance of Ruminiclostridium5 was associated with an increased risk of psoriasis. The genetically predicted relative abundance of Verrucomicrobiae, Verrucomicrobiaceae, Akkermansia, Verrucomicrobiales were positively associated with arthropathic psoriasis. A higher genetically predicted abundance of Rikenellaceae served as protective factors for arthropathic psoriasis. Specifically, a higher genetically predicted Atinomycetaceae, Eubacterium fissicatena group, Lactococcus, and Actinomycetales were associated with a higher risk of psoriasis vulgaris. In contrast, higher genetically predicted Odoribacter was a lower risk of psoriasis vulgaris. No significant heterogeneity or level pleiotropy of Instrumental variables estimation was found. Conclusion: This MR study offer novel perspectives regarding the prevention, advancement, and therapy of psoriasis by concentrating on specific bacterial groups. Additional research is required to specify the exact mechanism relating the association between gut microbiota and psoriasis along with its classifications.