Affiliation:
1. Social Welfare Organization Saiseikai Imperial Gift Foundation, Chibaken Saiseikai Narashino Hospital
2. Teikyo University School of Medicine
3. International University of Health and Welfare Narita Hospital
4. Chosei Municipal Hospital
5. National Institutes for Quantum Science and Technology QST hospital
6. Chiba Foundation for Health Promotion and Disease Prevention
7. Chiba University
Abstract
Abstract
Purpose
This study aimed to compare the outcomes of patients with ground-grass opacity (GGO)-dominant non-small cell lung cancer (NSCLC) who were treated with carbon ion radiotherapy (CIRT) versus segmentectomy.
Materials and methods
A retrospective review of medical records was conducted. The study included 123 cases of clinical stage 0/IA peripheral NSCLC treated with single-fraction CIRT from 2003 to 2012, 14 of which were determined to be GGO-dominant and were assigned to CIRT group. As a control, 48 consecutive patients who underwent segmentectomy for peripheral GGO-dominant clinical stage IA NSCLC were assigned to segmentectomy group.
Results
The patients in CIRT group, compared with segmentectomy group, were significantly older (75 ± 7.2 vs. 65 ± 8.2 years, P = 0.000660), more likely to be male (13/14 vs. 22/48, P = 0.00179), and had a lower forced vital capacity (91 ± 19% vs. 110 ± 13%, P = 0.0173). There was a significant difference in the 5-year overall survival rate (86% vs. 96%, P = 0.000860), but not in the 5-year disease-specific survival rate (93% vs. 98%, P = 0.368).
Discussion
Compared with segmentectomy, CIRT may be an alternative option for patients with early GGO-dominant NSCLC who are poor candidates for, or who refuse, surgery. (200 words)
Publisher
Research Square Platform LLC
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