Abstract
Muscari Mill. is used raw and cooked for gastric diseases, expectorants, wart treatment, and urine enhancers. No scientific study has been found on the effect of Muscari neglectum (MN) water extract on stomach diseases. Here, the effect of water extract of MN plant on some biochemical and histopathological parameters on indomethacin-induced gastric ulcer in rats was examined. In this study, 60 male Sprague Dawley rats were used for 24 acute toxicity and 36 gastric ulcer models (n = 6). They were divided into 6 groups as intact; indomethacin, famotidine, indomethacin and MN (100, 200, 400 mg/kg). The results of the gastric tissues examined biochemically, macroscopically and histopathologically showed that all doses of MN extracts prevented indomethacin-induced gastric mucosal damage and the 400 mg/kg dose had the strongest antiulcer effect with 69%. When SOD, GSH, CAT and MDA levels were investigated, the indomethacin-induced gastric ulcer group had a decrease in SOD, CAT and GSH levels and an increase in MDA levels. Additionally, LC-MS/MS analysis of the water extract of MN was performed and 14 phenolic compounds were determined. Biochemical analyses and histopathological examinations revealed that the water extract of MN has a good protective effect against gastric ulcer due to its high antioxidant content.