Discovery of N-Substituted Pyrazoline derivatives as novel 3-Benzo[b]thiophene and 2- Mercaptobenzimidazole inhibitor for the treatment of breast cancer

Abstract

Abstract A new series of pyrazoline derivatives 4(a-g) bearing 3-Benzo[b]thiophene and Benz imidazole thioether moiety were synthesised from substituted benzaldehyde and 2-acetyl benzo thiophene through Chalcones, followed by the cyclisation with hydrazine hydrate, acylation using chloroacetyl chloride and finally substituted with 1H-benzo[d]imidazole thiol. All synthesized compounds 4(a-g) were characterized by 1H NMR, 13C NMR and Mass spectra. The major scope behind the synthesis of these compounds is the immense biological activities associated to these heterocyclic derivatives against bacteria and fungi, anti-oxidant,anti-inflammatory and anti-cancer activity. Most of the compounds showed a fair degree of potent antimicrobial, anti-oxidant, anti-inflammatory and anticancer activity.