Comprehensive analysis of prognostic value and immune infiltration of CDK1 in lung cancer

Abstract

Abstract Objective: Lung cancer is one of the common malignant tumors worldwide with poor prognosis. Cyclin dependent kinase 1 (CDK1) plays crucial roles in regulating of cell cycle transition and is mainly involved in the development and progression of various tumors, however, little is known about its function in lung cancer. Methods: The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA), Clinical Proteomic Tumor Analysis Consortium (CPTAC) and Human Protein Atls (HPA) were used to evaluate the level of CDK1. Kaplan-Meier (K-M) Plotter, receiver operating characteristic (ROC) curve and Cox regression analyses were used to evaluate the value of CDK1 in lung cancer. Gene functional and pathways were assessed using Gene ontology (GO) analysis and gene set enrichment analysis (GSEA) The immune infiltration analysis was investigated basing on Single-sample gene set enrichment analysis (ssGSEA) . Results: The expression of CDK1 was significantly upregulatedin lung cancer patients, especially in those with advanced stage. Elevated CDK1 was associated with advanced clinical stage, shorter overall survival (OS) and disease specific survival (DSS) in lung cancer. Moreover, the functions of CDK1 were primarily related to cell cycle regulation and immune response. Most interestingly, the expression of CDK1 was associated with the infiltration immune cells and immune checkpoints. Conclusions: Our results revealed that CDK1 may be a diagnostic and prognostic biomarker in lung cancer. CDK1 plays a role in tumor immune evasion and may provide a potential therapeutic target to overcome immunity resistance in lung cancer.