Coronary Flow Velocity Reserve is Decreased in Patients with Restless Leg Syndrome

Abstract

Abstract IntroductionIn this study, we aimed to evaluate coronary endothelial dysfunction in restless legs syndrome(RLS) patients using coronary flow velocity reserve(CFVR) and compared it with healthy controls.MethodIn this study, the participants were divided into two groups as group RLS(n=42) and group HC(n=41). The primary outcome was the CFVR compared between groups. The number of participants with a CFVR value below 2.0 was also evaluated. In addition, a correlation between the international restless legs scale(IRLS) and CFVR, white-blood-cell-count(WBC), C-reactive-protein(CRP) were analyzed. Secondary outcomes were the WBC, hemoglobin, CRP, blood glucose, high-density-lipoprotein(HDL), low-density-lipoprotein(LDL), and creatinine compared between the two groups.ResultsA total of 116 participants were recruited for this study, and 83 participants(42 in Group RLS and 41 in Group HC) were ultimately enrolled. In the group RLS, CFVR was measured lower than healthy controls(p<0.001). When the groups were compared in terms of the number of participants with a CFVR less than 2.0, the difference between the groups was significant(p<0.001, 0/41 in group HC and 14/42 in group RLS).Patients with RLS had higher WBC and CRP values. There was a negative correlation between CFVR and IRLS(p<0.001). The relationship between WBC, CRP, and IRLS was not statistically significant(p=0.691).Discussion/ConclusionWe conclude that RLS patients had lower CFVR compared with healthy controls and there was a negative correlation between the severity of RLS and CFVR which indicates coronary endothelial function. Therefore, we think that it may be beneficial to follow up patients with RLS in terms of coronary heart disease.