Addressing Dementia Through Analysis of Population Traits and Risk Factors (ADAPTOR) using Australia’s largest cohort study: a study protocol

Author:

McNamara Martin1,Dolja-Gore Xenia2,Cavenagh Dominic3,D'Este Catherine4,Melo Luciano5,Jackson Kirsten6,Nepal Smriti1,Cresswell Adam1,Anstey Kaarin7,Brodaty Henry8,Welberry Heidi9,Goh Anita10

Affiliation:

1. Sax Institute

2. School of Medicine and Public Health, University of Newcastle

3. Centre for Women’s Health Research, University of Newcastle

4. National Centre for Epidemiology and Population Health, Australian National University

5. Health Education and Training Institute

6. Sydney Environment Institute, University of Sydney

7. School of Psychology, University of New South Wales

8. Centre for Healthy Brain Ageing, University of New South Wales

9. Centre for Big Data Research in Health, University of New South Wales

10. Department of Psychiatry, The University of Melbourne

Abstract

Abstract Background Dementia is a leading cause of disease burden in Australia, with almost half a million people living with dementia and a steady increase over time in dementia-related deaths. Strengthening the evidence base for dementia risk factors is critical for an effective and efficient public health and policy response. However, the number of Australians with dementia remains unknown, and there are significant gaps in the knowledge on risk factors in the Australian context. In this study we aim to develop reliable data on dementia incidence in Australia and investigate the associated risk factors, using a large population cohort. Specifically, we will assess the relative contribution of risk factors to dementia incidence as a basis for strengthening dementia prevention efforts. Methods We will use data from the 45 and Up Study that includes 267,358 residents of New South Wales, Australia, aged over 45 years, recruited between 2006-2009. To identify dementia cases we will link data from the 45 and Up Study with multiple health datasets containing information relevant to dementia case identification. We will estimate age- and sex-specific dementia incidence and model the association between dementia and risk factors related to socio-demographic characteristics, health conditions and health behaviours. We will also estimate the impact of various modifiable exposures on dementia incidence. Based on the results, we will produce a series of knowledge translation products providing advice on the contribution of identified risk factors to dementia incidence in Australia. Discussion Linking the 45 and Up Study data to multiple health datasets provides a unique opportunity to explore the role of risk factors on dementia incidence, including modelling the effect of modifiable risk factors on dementia incidence in the Australian population. We anticipate the results from this study to guide targeted and gradated strategies for population-level dementia prevention.

Publisher

Research Square Platform LLC

Reference37 articles.

1. What pharmacists need to know;Duong S;Can Pharm J (Ott),2017

2. Behavioural and psychological symptoms of dementia: a seven-tiered model of service delivery;Brodaty H;Med J Aust,2003

3. Managing behavioural and psychological symptoms in dementia;Macfarlane S;Australian prescriber,2016

4. Dementia Australia. Dementia statistics 2022 [updated January 2022; cited 2022 25 November 2022]. Available from: https://www.dementia.org.au/statistics.

5. Australian Bureau of Statistics. Causes of Death, Australia 2022 [updated 19 October 2022; cited 2022 25 November 2022]. Available from: https://www.abs.gov.au/statistics/health/causes-death/causes-death-australia/2021#key-statistics.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3