Systemic immune inflammatory index (SII) and urine albumin creatinine ratio (ACR) are associated with Diabetic macular epiretinal membrane

Abstract

Abstract Purpose To investigate the correlation between systemic immune inflammatory index (SII) or other metabolic index and diabetic macular epiretinal membrane (dERM) in hospitalized patients with diabetes mellitus (DM). Methods This retrospective study included 81 dERM inpatients and other 81 matched controls. Main indicators involved in comparison between group were macular volume coefficient, Body Mass Index (BMI), insulin usage rate, hypertension prevalence, SII, albumin (Alb), lipid indicators, uric acid, glycated hemoglobin and urine albumin creatinine ratio (ACR). Conditional logistic regression analysis was operated to evaluate the risk factors for dERM occurrence. Spearman correlation test was conducted to analyze the correlation between the above indicators in the dERM group and their Optical coherence tomography biomarkers. Results Each of macular volume coefficients, SII and ACR in the dERM group was significantly higher than those in the control group while Alb decreased (all p < 0.05). There was no significant difference in the rest of indicators between the two groups. Regression analysis predicted risk factors as SII (OR 3.92, 95% CI 1.90–9.65, p < 0.01) and ACR (OR 4.43, 95%CI 1.89–10.42, p < 0.01). Correlation analysis showed that hyperreflective foci (HRF), intraretinal cystoid space (IRC), and disorganization of retinal inner layers (DRIL) were all related to the thickness of the macular fovea. In addition, HRF showed a significant correlation with SII and ACR. IRC were also related to ACR, excepted DRIL. Conclusion Higher SII and ACR are closely related to dERM among DM hospitalized patients.