The value of fluorescence imaging in the intraoperative localization of small neuroendocrine tumors of the pancreas

Abstract

Objective To explore the effectiveness and safety of fluorescence imaging technology in the intraoperative localization of small neuroendocrine tumors of the pancreas. Methods Indocyanine green fluorescence imaging technology was used in operation, and the specific process of indocyanine green administration was as follows: 25 mg of indocyanine green was dissolved in 10 ml of sterilized water for injection, and 1 ml of indocyanine green was injected rapidly through the peripheral vein during the laparoscopic exploration of the tumor, and the tumor was observed to show green fluorescence about 1 min later, and the tumor showed green fluorescence, which was regarded as the success of development, and laparoscopic pancreatic tumor local excision surgery was carried out under the guidance of the real-time fluorescence imaging, and postoperative monitoring of the amylase index of drainage fluid to observe whether there was a pancreatic fistula. Under the real-time guidance of fluorescence imaging, laparoscopic pancreatic tumor local resection was performed, and the amylase index of the drainage fluid was monitored after surgery to observe whether pancreatic fistula occurred or not and to record the tumor grade, surgical margins, and other pathological conditions. RESULTS The fluorescence imaging effect of the two patients was good, the lesion boundary was clear, and both of them completed the local resection of the tumor laparoscopically without pancreatic fistula, and the pathology suggested that the pancreatic neuroendocrine tumors were grade G1, and the margins of the surgery were negative. CONCLUSION Fluorescence imaging technology helps to localize small pancreatic neuroendocrine tumors intraoperatively with good safety.