Synthesis and Characterization of Novel Substituted Bezaldehyde Derivatives of 4- Aminopyrrolo [2, 3-D] Pyrimidine

Abstract

Abstract The primary objective of this research was to synthesize, characterize, and evaluate the antibacterial and antifungal activities of novel pyrrolopyrimidine derivatives. The current research attempted to synthesise prrolopyrimidine derivatives containing substituted benzaldehydes (o-salicylaldehydes, m-salicylaldehydes, p-salicylaldehydes, 5-nitrosalicylaldehydes, 2,4-dimethoxybenzaldehyde, 2,5-dimethoxybenzaldehyde, 2,3-dihydroxybenzaldehyde, and 4-hydroxy-3-methoxybenzaldehyde). Spectral (IR, NMR, and UV) methods were used to characterize all of the synthesized compounds. The antibacterial and antifungal activities of the synthesized compounds were tested in vitro against two gram-positive bacteria (Staphylococcus aureus MCC 2010 and Bacillus subtilis MCC 2010), two gram-negative bacteria (Escherichia coli MCC 2412 and Pseudomonas aeruginosa MCC 2080), and two fungi (Candida albicans 1439 and S. cerevisiae MCC1033). In FT(IR), 1H and 13C NMR, and UV spectral analysis, all of the synthesized compounds showed remarkable peaks. In vitro antibacterial and antifungal activities revealed that e and g had more potent antibacterial and antifungal activities than the standard drugs streptomycin and fluconazole, respectively.