Effect of Gamma-Irradiated Borosilicate Glass on Ciprofloxacin Drug Delivery and Cytotoxicity: In-vitro Study for Medical Applications

Abstract

Abstract Modified borosilicate glasses (BSG) with the composition [50 B2O3-5 SiO2-15 ZnO-30 CaO] were fabricated with melt quenching technique. Samples were then irradiated with gamma radiation at dose rate of 1.4 kGy/h at a temperature of 30°C. Samples were characterized with Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDX). FTIR and SEM monitored the microstructural changes of BSG samples before and after gamma irradiation with doses of 50, 100 and 200 M rad, with 50 M rad step. Furthermore, to verify the transformation of the glass and the presence of bioactive glass particles in BSG samples, EDX was implemented to detect oxygen peaks, which are the main component of BSG. Later on, the efficacy of gamma-irradiated BSG in Ciprofloxacin drug delivery and cytotoxicity were studied to be dedicated for medical applications.