Abstract
The transforming growth factor-beta (TGF-β) subfamily regulates a magnificent spectrum of cellular processes and controls diseases, including cancer. The unique components of TGF-β had duplex roles in tumorigenesis. In tumorigenesis, TGF-beta has a tumour suppressive response observed by cell cycle block and cell death. So, TGF-β reveals a driving force of tumour elongation and metastasis by cumulative tumour cell interference and migration to promote therapeutic resistance. In this outlook, the study objected to identifying the TGFB domain-mediated gene in two mammalian genomes. So, perform bioinformatics and computational techniques to the current wisdom of the TGF-beta subfamily in two genomes. Primary observation demonstrated that the composition of nucleotides and peptides in the TGF-beta 1 gene in Homo sapiens. Also, the investigation forwarded the sum of TGFB domain-mediated genes in the TGF-beta subfamily in both organisms. Further analysis of TGF-beta 1 (target sequence), a unit of the TGF-beta subfamily, demonstrated the 3D structure, conserved domain, sequence motifs, phylogeny, gene expression and gene network, chromosome location, and pathways. Hence, the study outcome and proof of the molecular functions and mechanisms confirmed that the TGF-beta subfamily plays a fundamental role during tissue homeostasis in organisms.