Retinal Microperimetry as a Novel Tool for Early Detection of Cognitive Dysfunction and Brain Damage in Type 1 Diabetes: A Pilot Study

Author:

Mateu-Salat Manel1,Stanton-Yonge Nicole2,Santaló Frederic Sampedro3,Vela José Ignacio3,Cascajosa Jesús Díaz3,Pérez Eva Safont3,Chico Ana3

Affiliation:

1. Institut de Recerca Sant Pau (IR Sant Pau)

2. Hospital General de Granollers

3. Hospital Sant Pau

Abstract

Abstract Context: Retinal microperimetry (MPR) is a non-invasive method that measures retinal light sensitivity and gaze fixation stability (GFS). MPR has been described as an early marker of cognitive impairment in people with type 2 diabetes. Our group described subclinical cognitive alterations, structural brain differences, and increased levels of light chain neurofilament (NfL) in people with type 1 diabetes (T1D) and impaired awareness of hypoglycemia. The utility of MPR has not been described in T1D. Objective: to measure RS and GFS using MPR in individuals with T1D and evaluate possible differences depending on hypoglycemia awareness (IAH vs NAH). Secondary objectives: to perform a secondary analysis of correlation between MPR findings with neuropsychological assessment, plasma NfL levels, structural GM, and WM changes, and CGM-derived glucometric parameters, independently of hypoglycemia awareness. Design, setting and participants: Pilot observational study, adult people with type 1 diabetes without cognitive impairment, moderate-severe retinopathy, or glaucoma. MPR was performed with MAIA3. Results: 30 subjects were studied: 40% women, age 58 ± 11 years; T1D duration 31 ± 9 years, mild retinopathy 33%. RS was 27.5 dB (26.1–28.3) and GFS 97.6% (93.5–99.5%). We found a significant correlation between RS and memory alteration tests (p = 0.016) and between GFS and a composite of attention and executive neuropsychological tests (p = 0.025); between RS and insular cortical thickness (p = 0.04); RS and the right hippocampal volume (p = 0.02); and between GFS and the fractional anisotropy of thalamic radiations (p = 0.04). An inverse correlation between GFS and time below range was found. No correlation was found with NfL. Conclusion: Our exploratory study supports the potential utility of MPR as a screening tool for neurocognitive alterations and incipient structural brain damage in people with T1D.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3