Unveiling the oncogenic role of lncRNA 91H in liver Cancer: Implications for proliferation, migration, invasion, and epithelial-mesenchymal transition-Reference-Cited by-同舟云学术

Unveiling the oncogenic role of lncRNA 91H in liver Cancer: Implications for proliferation, migration, invasion, and epithelial-mesenchymal transition

Published:2023-08-24 Issue: Volume: Page:
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Author:

Mo Zhiyuan¹,Wang Zhuangqiang¹

Affiliation:

1. Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University

Abstract

Abstract Objective This study aimed to investigate the functional role of long ncRNA (lncRNA) 91H in liver cancer tumorigenesis, focusing on its effect on cell proliferation, apoptosis, cell cycle progression, migration, invasion, and epithelial-mesenchymal transition (EMT). Methods Liver cancer tissues and cell lines were analyzed for lncRNA 91H expression using quantitative methods. The functional role of 91H was assessed by silencing its expression in liver cancer cells. Cell proliferation was evaluated by measuring apoptosis induction and cell cycle progression. The migration and invasion capabilities of liver cancer cells were assessed and their impact on EMT was examined. Results Significantly higher levels of lncRNA 91H were observed in liver cancer tissues and cell lines than in normal cells. Silencing of 91H in liver cancer cells led to a notable reduction in cell proliferation by inducing apoptosis and arresting the cell cycle. Liver cancer cells with decreased 91H expression exhibited diminished migration and invasion abilities, suggesting a role for 91H in promoting these processes. Furthermore, 91H knockdown weakened EMT in liver cancer cells, indicating its involvement in modulating this critical cellular transition. Conclusion The findings of this study demonstrated that lncRNA 91H plays an oncogenic role in liver cancer. Its overexpression in liver cancer tissues and cell lines is associated with increased proliferation, migration, invasion, and EMT. Silencing 91H resulted in the inhibition of cell proliferation and reduced metastatic potential, suggesting its potential prognostic and therapeutic value in liver cancer. Further exploration of the molecular mechanisms underlying the involvement of 91H may provide valuable insights into liver cancer progression, and contribute to the development of more effective therapeutic strategies.

Publisher

Research Square Platform LLC

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