Synchronous Multiple Pulmonary Ground-Glass Nodules That Arose from Different Lesions Rather than from Multiple Metastases of a Single Lesion

Author:

HAN Ya-Qing1,HAN Wen-Yu2,XIE Shao-Nan1,LIU Qing-Yi1

Affiliation:

1. Department of Thoracic Surgery, The Fourth Hospital of Hebei Medical University

2. Department of Thoracic Surgery, Hebei Provincial People's Hospital

Abstract

Abstract Purpose This study aimed to investigate the expression of lung cancer driver genes in patients with synchronous multiple ground-glass nodules (SMGGNs), to calculate the relationships of these genes with clinical features, and to probe into the origin of multiple primary pulmonary ground-glass nodules (GGNs) from the perspective of molecular biology. Methods The clinicopathological data of 50 patients with SMGGNs who were admitted to the Department of Thoracic Surgery of the Fourth Hospital of Hebei Medical University from January 2018 to January 2021 were collected for retrospective analysis. All the samples resected were genotyped at 16 lung cancer driver gene loci by next-generation sequencing technology. The relationships between gene mutations and clinical features were analysed, and suspected pulmonary nodules of the same origin were analysed by the whole-exome sequencing. Results Fifty patients were included in the study, 86.0% (43/50) of whom had gene mutations. Some 133 pulmonary nodules were resected, which were pathologically classified into the following types: atypical adenomatous hyperplasia (21 nodules), adenocarcinoma in situ (32), micro-invasive adenocarcinoma (30), and invasive adenocarcinoma (50). Lung cancer driver gene mutations were identified in 73 (54.9%) nodules, 63.0% (46/73) of which were in the epidermal growth factor receptor gene (EGFR). Significant differences were observed in the gene mutation status between nodule types, particularly EGFR mutation, which differed between histological and imaging subtypes. Multiple gene mutations were not discovered in the same tissue. A low-probability mutation (RET fusion) was detected in three nodules of one patient, and further whole-exome sequencing showed that the three nodules had different gene mutations and were not metastatic. Conclusions The driver gene mutations in patients with SMGGNs are quite different and mutually exclusive, and nodules can arise from multiple primary lesions. Surgical resection is considered a superior approach to treating SMGGNs.

Publisher

Research Square Platform LLC

Reference47 articles.

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3