Abstract
Background Hospitalization for sepsis may be associated with an increased riskfor cardiovascular events. We aim to explore the relationship between sepsis hospitalization and long-term of cardiovascular events, and describe risk factors for cardiovascular events in adults sepsis survivors.
Methods MEDLINE, EMBASE, Cochrane Library, Wanfang, and CNKI were searched, from inception to Aug 2023, and no language limitation. Cumulative incidence and hazard ratios (HRs) with 95% confidence interval (CI) was used to assess the strength of the association.
Results 25 observational studies were included in this meta-analysis. The pooled cumulative incidence of major cardiovascular was 9.0%, myocardial infarction was 2.4%, stroke was 4.9% and congestive heart failure was 8.6%. Sepsis hospitalization was associated with a higher long-term risk of major cardiovascular(HR, 1.54; 95% CI 1.32- 1.79), myocardial infarction (HR, 1.41; 95% CI 1.29- 1.54), stroke (HR, 1.45; 95% CI 1.32- 1.60) and congestive heart failure (HR, 1.51; 95% CI 1.46- 1.56) compared to non-sepsis controls. Pooled analysis indicate that age≤ 45 years, male gender, hyperlipidaemia, and some comorbidities were significantly associated with increased hazards of cardiovascular events.
Conclusions Adults sepsis survivors may be experience a higher hazard of cardiovascular events compared to non-sepsis controls. And both common cardiovascular risk factors and sepsis-related variables can significantly increase this correlation.