Management, clinical Outcomes, and Its Predictors among Heart Failure Patients Admitted to Tertiary Care Hospitals in Ethiopia: Prospective Observational Study

Author:

Beri Berhanu1,Fanta Korinan1,Bekele Fekede1,Bedada Worku2

Affiliation:

1. Jimma university, Clinical Pharmacy Course and Research Team

2. Former Dean and Research Director of Salale University

Abstract

Abstract Background Heart failure is a global pandemic, as it affects approximately 64.34 million people worldwide with a $346.17 billion global economic burden. The prevalence of heart failure has increased from 43.4–46.5% in the last 10 years in lower and middle-income countries. This study aimed to assess management, clinical outcomes and their predictors among heart failure patients admitted to tertiary care hospitals in Ethiopia. Methods A prospective observational study design was conducted on heart failure patients admitted at two tertiary care hospitals in Ethiopia from September 2020 to May 2021. The primary outcome of the study was 90-day all-cause mortality. Data were analyzed using SPSS version 23.0. A multivariate Cox regression model was performed to identify independent predictors of 90-day all-cause mortality. Variables with P-values < 0.05 were considered statistically significant. Results Out of 283 patients enrolled in this study, 52.3% were male and the mean (± SD) age was 52.4 ± 17.9 years. The most common medications prescribed during hospitalization and discharge were diuretics (98.9% vs 95.6%), ACEIs/ARBs (48.8% vs 67.3%), and beta-blockers (46.6% vs 64.7%), respectively. In the present study, the 90-day all-cause mortality was 10.2%. Hypertension (HR = 3.70, 95%CI = 1.18–11.61), cardiogenic shock (HR = 8.66, 95%CI = 3.15–20.82), and reduced ejection fraction (HR = 1.47, 95%CI = 1.06–3.79) were predictors of 90-day all-cause mortality. Conclusion High 90-day all-cause mortality was observed among heart failure patients in the present study. Alcohol drinking, hypertension, cardiogenic shock, and reduced ejection fraction were predictors of poor treatment outcomes for whom closer follow-up or further interventions may be considered.

Publisher

Research Square Platform LLC

Reference33 articles.

1. Bozkurt B, Hershberger RE, Butler J, Grady KL, Heidenreich PA, Isler ML, et al. 2021 ACC/AHA Key Data Elements and Definitions for Heart Failure: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Heart Failure). American College of Cardiology. 2021;77(16):2053–150.

2. Heart failure: Definition, classification, and pathophysiology–A mini-review;Adebayo SO;Nigerian Journal of Cardiology,2017

3. The burden of cardiovascular diseases in Ethiopia from 1990 to 2017: evidence from the Global Burden of Disease Study;Ali S;J International Health,2020

4. Global epidemiology and future trends of heart failure;Lippi G;AME Med J,2020

5. Adherence to self-care recommendations and associated factors among adult heart failure patients. From the patients’ point of view;Seid MA;J PloS one,2019

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