Meta-analysis of the efficacy of titanium alloy ossicles and autologous ossicles in ossiculoplasty A survey to evaluate the efficacy of titanium alloy ossicles

Abstract

Abstract Background：Chronic suppurative otitis media destroys the ossicular chain，which can be cured by ossiculoplasty using different materials. We were interested in the material which may have a different effect on the recovery outcome and carried out this review. Methods：A meta-analysis to compare the efficacy of titanium alloy ossiculoplasty with autologous ossiculoplasty was conducted. In addition to the published Chinese literature, other unpublished internal data were also collected, and the quality of the literature was scored according to the inclusion and exclusion criteria. A meta-analysis of the sample data was performed using Review Manager 5.0 statistical software. In the meta-analysis of the single-group rate, I2 was greater than 50, the data analysis used a random model, the combined rate was basically the same and the P values were less than 0.05. Results：The meta-analysis of efficacy comparisons showed that the data for titanium alloy ossicles and autologous ossicles were basically the same for air-conduction hearing and bone-conduction hearing. The combined effect size of air-conduction hearing was -3.8, the 95% confidence interval (CI) was -5.7– -1.89 and the combined effect size of bone-conduction hearing was -5.7–-1.89. The effect size was 0.85, and the 95% CI was -1.31–3. The follow-ups at three months and six months and the postoperative adverse reaction rate were significantly better when titanium alloy ossicular bone was used for ossiculoplasty than autologous ossicular bone. The homogeneity of the study effect size was significant (I2 = 0, P > 0.05), and a fixed-effects model was used; the P value was less than 0.05, so the data were statistically significant. Conclusion：In conclusion, for ossiculoplasty, titanium alloy is an effective material with good clinical results. Trial registration: The protocol was registered at PROSPERO-International prospective register of systematic reviews (Centre for reviews and dissemination, University of York, York, United Kingdom). CRD42022364358.