Affiliation:
1. Korea University Medical Center
Abstract
Abstract
Background The role and clinical utility of the cell adhesion molecule (CAM) have been studied in several malignancies. However, there have been few studies of the role of the CAM in gallbladder cancer. The aim of this study is to evaluate the clinical utility and the value as a prognostic factor of the CAM in gallbladder cancer. MethodsThe expression of CAMs (E-cadherin, E-selectin, ICAM-1 and VACM-1) of the tissues from 25 malignant and 25 benign gallbladder disease patient who were operated between January 2005 and July 2009 at Korea University Ansan Hospital were analyzed by immunohistochemical stain and real time polymerase chain reaction (PCR). And the correlation of expression of CAMs with clinicopathological variables were evaluated.ResultsThe expressions of E-cadherin, ICAM-1 and VACM-1 on immunohistochemical stain of malignancy group were decreased with statistically differences compared to benign group (p<0.001, p=0.01 and p=0.001, respectively). The ratio of E-selectin and ICAM-1 in the gallbladder cancer tissues was significantly decreased on real time PCR (p=0.009 and p=0.034, respectively), and the alteration of expression in E-selectin was significantly correlated to cell differentiation(p=0.023), T stage(p=0.005) and TNM stage(p=0.023).ConclusionsThis result could be a base of the alteration of expression of CAMs and suggests the possibility that E-selectin may be used in prediction of outcomes of gallbladder cancer and expected to be used in practice.
Publisher
Research Square Platform LLC
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