The mechanical and antibacterial properties of bone cement composites containing silver nanoparticles compounded with various chitosans

Author:

Li Zhuoyang1,Yang Xin1,Cao Yongping1,Meng Zhichao1,Liu Heng1,Wang Rui1,Wu Hao1

Affiliation:

1. Peking University First Hospital

Abstract

Abstract Objective: To analyse the mechanical and antibacterial properties of bone cement composites containing silver nanoparticles (AgNPs) compounded with chitosan (CS) and carboxymethyl chitosan (CMCS).Methods: Ten percent wt% AgNPs, CS-AgNPs and CMCS-AgNPs were prepared through an oxidation-reduction reaction under sonic oscillation and mix with polymethyl methacrylate (PMMA). The compressive and bending strengths of these nanoparticles were measured before and after soaking the samples in simulated body fluid (SBF). The Kirby-Bauer (K-B) method and flask oscillation method were used to evaluate the antibacterial effects of the composites. Results:The compressive and bending strengths of the AgNP, CS-AgNP, and CMCS-AgNP groups were significantly improved (P < 0.001). After soaking in SBF, the bending strengths of the AgNP, CS-AgNP, and CMCS-AgNP groups were significantly higher than that of the control group (P < 0.001). The K-B test showed only the 5 wt% and 10 wt% CMCS-AgNP groups exhibited bacteriostatic rings for Staphylococcus aureus and methicillin-resistant Staphylococcus aureus (MRSA). The flask oscillation analyses revealed that the 5 wt% and 10 wt% CMCS-AgNP exhibited good bacteriostatic activity against S. aureus, but only the 10 wt% CMCS-AgNP group for MRSA.Conclusion: We developed CS/CMCS-AgNP bone cement composites, which show good mechanical properties and antibacterial activity.

Publisher

Research Square Platform LLC

Reference56 articles.

1. The epidemiology of revision total knee and hip arthroplasty in England and Wales: a comparative analysis with projections for the United States. A study using the National Joint Registry dataset;Patel A;Bone Joint J,2015

2. Which Clinical and Patient Factors Influence the National Economic Burden of Hospital Readmissions After Total Joint Arthroplasty?;Kurtz SM;Clin Orthop Relat Res.,2017

3. Combinatorial discovery of polymers resistant to bacterial atachment[J];Hook AL;Nat Biotechnol,2012

4. Engineering serendipity: High-throughput discovery of materials that resist bacterial attachment;Magennis EP;Acta Biomater,2016

5. Chitosan-based hydrogel beads: Preparations, modifications and applications in food and agriculture sectors - A review;Qu B;Int J Biol Macromol,2020

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3