Affiliation:
1. University of Chicago
2. University of Ibadan
3. Lagos State University
4. Mulago Hospital
5. Hôpital Général Yaoundé
Abstract
Abstract
Purpose
To examine the association between benign breast disease (BBD) and breast cancer (BC) in a heterogeneous population of African women.
Methods
BC cases and matched controls were enrolled in three sub-Saharan African countries, Nigeria Cameroon, and Uganda, between 1998–2018. Multivariable logistic regression was used to test the association between BBD and BC. Risk factors dually associated with BBD and BC were selected. Using a parametric mediation analysis model, we assessed if selected BC risk factors were mediated by BBD.
Results
Of 6418 participants, 55.7% (3572) were breast cancer cases. 360 (5.7%) self-reported BBD. Fibroadenoma (46.8%) was the most reported BBD. Women with a self-reported history of BBD had greater odds of developing BC than those without (adjusted odds ratio [aOR] = 1.47, 95% CI: 1.13–1.91). Biopsy-confirmed BBD was associated with BC (aOR = 3.11, 95% CI: 1.78–5.44). BBD did not significantly mediate the effects of any of the selected BC risk factors.
Conclusions
In this study, BBD was associated with BC and did not significantly mediate the effects of selected BC risk factors.
Publisher
Research Square Platform LLC
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