Affiliation:
1. The Affiliated Taizhou People's Hospital of Nanjing Medical University
2. Nanjing University of Chinese Medicine
Abstract
Abstract
Objective
To analyze the correlation between antimicrobial resistance of Klebsiella pneumoniae in ICU and the use of antibiotics, to provide evidence and reference for rational use of antibiotics and prevention and control of multi-drug resistant bacteria.
Methods
The composition ratio and the antibiotic resistance rate of Klebsiella pneumoniae isolated in ICU from 2020 to 2022 was analyzed retrospectively, as well as the correlation between the antibiotic use density and antibiotic resistance were analyzed.
Results
971 strains of Klebsiella pneumoniae isolated from ICU for three years were selected. The samples were mainly derived from sputum (72.50%), urine (10.40%), drainage fluid (7.00%), blood (6.80%). The antibiotic resistance rate of Klebsiella pneumoniae was 48.6%, and there was significant difference in the antibiotic resistance rate of all kinds of antibiotics (P < 0.001).The resistance rate of Klebsiae pneumoniae to β-lactam and quinolone antibiotics was higher (> 50%). The resistance rate to Carbapenems, aminoglycosides and sulfonamides was relatively low (< 40%). There was a significant positive correlation between the resistance rate of Klebsiella pneumoniae and the antibiotics use density (P < 0.05).
Conclusion
The antibiotic resistance of Klebsiella pneumoniae is severe, which is significantly related to the antibiotic use density. We should strengthen the management of antibiotic, and strictly implement the prevention and control measures of multi-drug resistant bacteria to reduce the spread of resistant.
Publisher
Research Square Platform LLC
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