Identification of a Disulfidptosis-Related Gene Signature for Prognostic Implication in Colon Adenocarcinoma

Abstract

Abstract We aimed to find genes related to disulfidptosis, a type of cell death that may affect cancer development. Disulfidptosis is a new research topic. We wanted to find genes related to disulfidptosis, a new type of cell death caused by excess cystine in cells. Disulfidptosis may affect cancer development differently from other types of cell death. We focused on colon adenocarcinoma (COAD), which is the second most deadly cancer worldwide and has been increasing rapidly in recent years. Tumor biomarkers can help diagnose and monitor tumors, so we need to find new ones for COAD and develop new treatments. We analyzed the mRNA expression data and clinical information of COAD patients from public databases. We used a machine-learning algorithm to select key features and build a signature. We found four genes that are involved in disulfidptosis: TRIP6, OXSM, MYH3 and MYH4. These genes can predict how long COAD patients will live. We also found that these genes affect the tumor microenvironment (TME), drug sensitivity and immune microenvironment of COAD patients. Our study shows that disulfidptosis-related genes are important for COAD prognosis and therapy. This is crucial for developing personalized cancer therapy.