Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Abstract

Abstract Introduction: The COVID-19 pandemic and pre-eclampsia both present significant health challenges worldwide, with emerging evidence suggesting a genetic interlinkage that could illuminate new therapeutic avenues. This study aims to explore the genetic relationship between the severity of COVID-19 and pre-eclampsia, with a focus on Single Nucleotide Polymorphisms (SNPs) in the NTSR1 gene and mechanisms of calcium ion transport. Method: We employed a combination of genetic epidemiology and molecular biology techniques, including comprehensive bibliometric analysis and Mendelian Randomization, to assess the correlation between specific SNPs related to the NTSR1 gene and the severity of both COVID-19 and pre-eclampsia. Result: Our findings reveal a significant genetic correlation between the severity of COVID-19 and pre-eclampsia, underscored by SNPs associated with the NTSR1 gene and calcium ion transport. This correlation suggests a shared genetic foundation that could exacerbate both conditions, providing insights into potential molecular interactions involved. Conclusion: The identification of shared genetic pathways between COVID-19 and pre-eclampsia highlights the importance of genetic insights in developing targeted therapeutic interventions. These results open up new avenues for the mitigation of these conditions, emphasizing the role of genetic epidemiology in shaping future healthcare strategies.