Histological and genetic changes induced by extracorporeal shockwave therapy after rotator cuff repair in a rat model with tears

Author:

Kamiyama Masataka1,Shitara Hitoshi1,Ichinose Tsuyoshi1,Sasaki Tsuyoshi1,Miyamoto Ryosuke1,Ino Fukuhisa1,Hamano Noritaka1,Nakase Kurumi1,Koibuchi Noriyuki2,Chikuda Hirotaka1

Affiliation:

1. Department of Orthopaedic Surgery, Gunma University Graduate School of Medicine

2. Department of Integrative Physiology, Gunma University Graduate School of Medicine

Abstract

Abstract

The histological and genetic changes associated with significant tendon-to-bone differences after extracorporeal shockwave therapy (ESWT) are unknown. This controlled laboratory study investigated the histological and genetic changes in the rotator cuff induced by ESWT. Twenty-two retired male Wistar rats were induced with left supraspinatus tendon ruptures. Three weeks later, rotator cuff repair was performed. One week post-repair, the rats were randomly assigned into either the ESWT or control group, with 11 rats in each group. Compared with the control group, the ratio of cellularity was significantly lower, and that of collagen fiber orientation was significantly higher in the ESWT group. The number of blood vessels and the total histological scores were not significantly different between the two groups. Real-time polymerase chain reaction analysis revealed that the mRNA expressions of CCN2 and SCX were significantly higher in the ESWT group than in the control group. No statistically significant differences were found between the SOX9 and Tnmd expressions. ESWT induces histological changes and increases the messenger RNA expressions of CCN2 and SCX in rotator cuff repair of chronic tears in rats. ESWT is a potential method for promoting histological and cytological changes associated with improving the mechanical strength of rotator cuff repair.

Publisher

Springer Science and Business Media LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3