Abstract
Background
Chronic inflammation related to dietary was linked to pancreatic cancer (PC) risk. This meta-analysis aimed to investigate the association between the PC risk and Dietary Inflammatory Potential (DIP).
Methods
As of January 24, 2024, seven databases including Embase, PubMed, Web of Science, Cochrane Library, Wanfang, China National Knowledge Infrastructure (CNKI), and Chinese VIP were searched to identify relevant studies. Studies reported RR and corresponding 95% CI for the DIP category and PC risk were included.
Results
Pooled RR indicated that compared with the lowest DIP scores category, individuals in the highest category had a 33% increased risk of PC (RR = 1.35; 95% CI: 1.11–1.64). Subgroup analysis revealed that PC risk and DIP scores seemed to be positively correlated in case-control studies (RR = 1.78; 95% CI: 1.55–2.05). No positive results with low heterogeneity were found in subgroups divided according to measurement tool, nutrient component number and the variables adjusted for. Dose-response meta-analysis showed the relationship between DIP scores and PC risk conformed to a linear model (Wald test χ2 = 4.0, P = 0.14), with PC risk increasing by 5.4% for every 1-unit increase (RR = 1.05, 95% CI: 1.00–1.11)
Conclusion
This meta-analysis highlighted dietary habits with high inflammatory potential may increase PC risk.
(PROSPERO) International prospective register of systematic reviews:
CRD42023478446