Affiliation:
1. The First Hospital of Jilin University, Jilin University
Abstract
Abstract
Background: Studies have shown that uric acid (UA) crystals can induce immune responses in the body; however, the relationship between soluble UA and immune responses remains unknown.
Methods: We retrospectively analyzed and compared peripheral blood immune cells and cytokine levels in healthy individuals with high or normal serum uric acid (SUA) levels. We used soluble UA to stimulate peripheral blood mononuclear cells in vitro and examined lymphocyte subset counts and activation.
Results: The number of immune cells in healthy individuals with high SUA levels increased, with the most obvious increase being observed in lymphocytes, mainly in CD4+ T cells. Lymphocyte elevation was more pronounced in women, who showed increased CD19+ B cell counts. Concomitantly, IL-4 and IL-10 levels significantly increased in healthy individuals with high SUA levels. In vitro, soluble UA promoted the proliferation and activation of CD4+ T and CD19+ B cells.
Conclusions: Our study revealed that elevated soluble UA levels may cause peripheral lymphocytes counts increase and make healthy subjects in a Th2-dominant immune status.
Publisher
Research Square Platform LLC
Reference28 articles.
1. Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout;Wang Z;Frontiers in cellular and infection microbiology,2022
2. Induction of ROS Overload by Alantolactone Prompts Oxidative DNA Damage and Apoptosis in Colorectal Cancer Cells;Ding Y;International journal of molecular sciences,2016
3. Definition of hyperuricemia and gouty conditions;Bardin T;Current opinion in rheumatology,2014
4. The interaction between uric acid level and other risk factors on the development of gout among asymptomatic hyperuricemic men in a prospective study;Lin KC;The Journal of rheumatology,2000
5. Urate crystal deposition in asymptomatic hyperuricaemia and symptomatic gout: a dual energy CT study;Dalbeth N;Annals of the rheumatic diseases,2015