Reconstruction of the Frontal Aslant Tract (FAT) in patients with different types of frontal lobe tumors, considering diverse methods of delineation

Abstract

Abstract The Frontal Aslant Tract (FAT) is a bundle of nerve fibers located in the brain that connects the frontal lobe to the pars aslant of Broca's area. It serves as a crucial neural pathway involved in language regulation, speech, and motor control. The FAT is part of the broader cingulo-fronto-parietal network, facilitating communication between the frontal and posterior regions of the brain. The objective of this study is to investigate the connectivity of the Frontal Aslant Tract using diffusion tensor imaging-based fiber tractography analysis. We compared the fiber count, tract length, shape, and projections of the FAT in patients with frontal tumors to a control group. Among patients diagnosed with brain tumors, we observed a reduction in the number of nerve fibers within the FAT and a decrease in pathway volume. When delineating the FAT using ROIs encompassing the superior frontal gyrus and endpoint in the pars opercularis of the inferior frontal gyrus, we obtained the highest fiber count. The specific anatomy of the FAT is heavily influenced by the choice of ROI and endpoint. Accurate identification of the FAT in patients with frontal lobe tumors is crucial to prevent postoperative aphasia.