Affiliation:
1. China Academy of Chinese Medical Sciences
2. China traditional Chinese medicine science and technology development center
Abstract
Abstract
Background:
This study aimed to assess the prevalence and identify risk factors associated with depression among coronary heart disease (CHD) patients at different stages in China.
Methods:
Conducted as a hospital-based, cross-sectional study across 48 hospitals in 23 provinces, the research spanned from October 2016 to April 2018. A total of 9044 patients were initially recruited, with 8353 deemed eligible for participation. Depression was assessed using the nine-item Patient Health Questionnaire-9 (PHQ-9) Scale. Univariate analysis identified predictors of postoperative depression, and binary logistic regression analysis was employed to ascertain risk factors associated with depressive symptoms. The predictive model was constructed using the "rms" package in R software, demonstrating robust predictive capabilities according to the ROC curve.
Results:
In general, both the degree and overall score based on the PHQ-9 revealed a trend: as the severity of the disease increased, so did the severity of patient depression. Univariate analysis indicated statistical differences concerning general situations and lifestyles. The binary logistic regression model highlighted the proximity of depression to risk factors such as gender, nationality, marital status, education, drinking, BMI, sleep disturbance, and disease status. Utilizing these findings, a predictive nomogram for depression was developed. The model exhibited excellent predictive ability, with an AUC of 0.768 (95% CI = 0.757–0.780).
Conclusions:
This study systematically investigated the prevalence of depression among coronary heart disease patients at various stages. As coronary heart disease advanced, the level of depression intensified. The nomogram developed in this study proves valuable in predicting the incidence of depression in coronary heart disease patients.
Publisher
Research Square Platform LLC
Reference36 articles.
1. RICHARDS S H, ANDERSON L, JENKINSON C E, et al. Psychological interventions for coronary heart disease [J]. The Cochrane database of systematic reviews, 2017, 4(4): Cd002902.
2. Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association [J];TSAO C W;Circulation,2022
3. The anxious heart in whose mind? A systematic review and meta-regression of factors associated with anxiety disorder diagnosis, treatment and morbidity risk in coronary heart disease [J];TULLY P J, COSH S M BAUMEISTER H;Journal of psychosomatic research,2014
4. Depression and coronary heart disease [J];CARNEY RM;Nature reviews Cardiology,2017
5. Mental disorders across the adult life course and future coronary heart disease: evidence for general susceptibility [J];GALE C;Circulation,2014