Serum Lactate Dehydrogenase(LDH) and Gamma-Glutamyl Transferase (GGT) Correlate Optimally with Nottingham Prognostic Index for Breast Cancer

Abstract

Background LDH and GGT have been identified as breast cancer serum prognostic markers. Serum level of LDH has been found to increase due to uplifted anaerobic glycolysis in malignant neoplastic conditions. GGT has also been noted to rise in circulation indicating the extent of oxidative stress within the body. Their levels are high in advanced BC cases. Meanwhile, in our setting, there are no serum markers done on a routine basis in breast cancer surveillance among women and predicting the prognosis. Thus, these markers can augment the available tool(s) in predicting breast cancer prognosis since they are widely available, accessible, and economically affordable. Objective This study aimed to assess the correlation between LDH/GGT with NPI among Breast Cancer Women. Study Methods A prospective cross-sectional study was conducted for 12 months. The data were collected by interviewing patients, patients’ files and from the hospital’s electronic database (Jeeva) and then were filled in the structured checklist. IBM SPSS version 27 was used to analyse the data. Mean, median and standard deviation were used to present numerical variables. Categorical variables were presented as frequencies or proportions The correlation was assessed and analyzed by Spearman correlation coefficient and Linear Regression models while ROC was used to determine the accuracy. Results Out of the 104 patients who underwent radical mastectomy for Breast Cancer had a mean age of 48.51 ± 12.80. Among them, 27 (26%) were diagnosed below 40 years of age.