The underestimation and overestimation accuracy in MRI and SWE compare with the radical prostatectomy, Validation technique using tissue-mimicking phantom

Abstract

Abstract Over the last few years, a number of studies have quantified the limitation of the MRI in quantifying the prostate lesion compared with radical prostatectomy; therefore, the aim of this paper was to assess the size measurements of the prostate cancer lesions by MRI, and SWE compared with radical prostatectomy and to validate the findings by a tissue mimicking phantoms. This study used 16 prostate cancer tissue-mimicking phantoms to obtain preclinical data. We then focused on 31 patients who have undergone mpMRI, SWE, and radical prostatectomy between September 2016 and December 2017. The T-test was used to assess how the significant difference between the imaging modalities MRI, SWE, and the gold standard in clinical and preclinical. Statistically, there was a significant difference between the size measurement of MRI and SWE compared with radical prostatectomy. However, there was no significant difference in pre-clinical when these modalities were compared with the phantom. SWE evidenced a higher detection of prostate cancer compared with MRI since out of the 102 tumours reported by the pathologist, only 57 tumours were reported by the radiologists through MRI, and 72 tumours were reported by the SWE. Both MRI and SWE showed significant differences in the size measurements of the prostate cancer lesions compared with the radical prostatectomy, but SWE showed a higher detection of smaller lesions (less than 10 mm) compared with MRI.