Affiliation:
1. The Second Affiliated Hospital of Soochow University
2. Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medicine
3. Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University,
4. Department of Neurology, The Second Affiliated Hospital of Soochow University
Abstract
Abstract
Objective: To investigate the association between lower urinary tract symptoms (LUTS), Parkinson's disease (PD) progression, and the presence of REM sleep behavior disorder (RBD) in PD patients.
Methods: A total of 897 PD patients from the Long-term follow-up database of Parkinson's disease (LEAD-PD) were included in the study. The prevalence of LUTS and its association with RBD, non-motor symptoms, and disease severity were analyzed. Intergroup comparisons, subgroup analysis, logistic regression and ROC curve analyses were used to identify clinical features associated with LUTS.
Results: LUTS is common in patients with PD, with nocturia being the most frequent symptom. LUTS is correlated with disease severity (UPDRS I to IV, p<0.001), cognitive function (MMSE, p<0.001), depression (HRSD, p<0.001), and quality of life (PDQ39, p<0.001). The presence of RBD significantly increased the occurrence of LUTS, particularly urinary urgency (p<0.001) and frequency (p<0.001), in both male and female PD patients. RBD combined with non-motor symptom scores (NMSQ), UPDRS I or quality of life scores (PDQ39) served as a highly sensitive predictor for the onset of urinary urgency (AUC=0.881) and frequency (AUC=0.915) in PD patients.
Conclusion: RBD is an independent risk factor for LUTS in patients with PD. it is crucial to strengthen the prevention and treatment of LUTS symptoms in PD-RBD patients. Further research exploring the pathological and physiological mechanisms by which RBD leads to LUTS symptoms can provide a deeper understanding of the occurrence and progression of PD, paving the way for the development of innovative treatments.
Publisher
Research Square Platform LLC