Major Depressive Disorder Trait Genes Promote Triple-Negative Breast Cancer Progression and Predict Immunotherapy Responses

Abstract

Abstract TNBC is the most malignant subtype of breast cancer and there are no accurate and effective therapeutic targets. Immunotherapy is a promising approach for the treatment of TNBC. Anxiety and depression are among the most common concomitant symptoms in BC.MDD affects the functioning of the immune system, and its immune-related genes not only influence the pathophysiology of MDD, but may also increase the risk of BC recurrence and metastasis. This study revealed significant differences in T-lymphocyte infiltration between the high-risk and low-risk groups of TNBC differentiated on the basis of the characteristic inflammatory genes of MDD, which can help to screen the population for immunotherapy benefit and provide new ideas for future immunotherapy of TNBC. We aimed to identify MDD-related genes involved in the pathogenesis of TNBC and to provide predictive immunotherapy biomarkers for TNBC.