Abstract
Background To determine the association of calcified necrotizing funisitis with adverse neonatal outcomes.
Method This retrospective study included newborns who had undergone pathological examination between July 2020 and March 2024. Twenty-one neonates who delivered at Jinan Maternal and Child Health Hospital with pathological results of calcified NF were retrospectively selected as the study subjects, and 44 neonates who were admitted during the same period without pathological results of calcified NF were selected as the control group according to a gestational age ratio of 1:2. Neonatal outcome measures were comparable between the two groups.
Results Two groups were born preterm. Compared to those in the control group, the mode of delivery (cesarean vs vaginal), prolonged PROM, RDS, ROP, duration of ventilator use, white cell count, CRP, and neutrophil percentage in the observation group were significantly different from those in the control group (P<0.05). Among the 21 individuals analyzed, 14 patients (66.7%) were determined to be positive for UU infection in the observation group, and 4 patients (9.50%) were positive in the control group. The differences were statistically significant (P<0.001).
Conclusion Blood cell counts, CRP levels and neutrophil proportions were markedly elevated. The rates of RDS and ROP decreased. The duration of invasive mechanical ventilation use was prolonged in neonates with calcified necrotizing funisitis. UU was a risk factor for calcified NF.