Correlation between gestational diabetes and peripartum mental disorders: A meta-analysis of 1,636,131 patients .Running title :A meta-analysis about correlation between gestational diabetes and peripartum mental disorders

Abstract

Abstract Background and Aim The relationship between gestational diabetes mellitus (GDM) and peripartum mental disorders is unclear. Hence, the current meta-analysis aimed to systematically evaluate the risk of mental disorders in pregnant women with or without GDM. Methods We searched the PubMed, Cochrane Library, EMBASE, and Web of Science databases for relevant articles published up to October 30, 2021. The random-effects or fixed-effects model was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for the prevalence of mental disorders in GDM. Sensitivity and subgroup analyses were conducted to test the robustness of the pooled estimates. Results We analyzed 32 studies involving 1,636,131 pregnant women, and the results demonstrated that GDM significantly increased the prevalence of peripartum depression (antenatal, pooled OR: 1.57, 95% CI: 1.33–1.85, P < 0.05; postpartum, pooled OR: 1.42, 95% CI: 1.18–1.70, P < 0.05), especially in women from Asia (pooled OR: 2.71, 95% CI: 1.98–3.72, P < 0.05). Compared to pregnant women without GDM, women with GDM reported significantly higher anxiety scores (pooled OR: 4.19, 95% CI: 1.21–7.17, P = 0.006) but insignificantly on antenatal stress symptoms while this evidence still needs to be further strengthened. Conclusions GDM significantly increased the prevalence of antenatal and postpartum mental disorders. Further multi-center prospective studies with long-term follow-up are required to verify the association between GDM and mental health.