Affiliation:
1. Inha University
2. Chonnam National University Medical School
Abstract
Abstract
Piperine, a dietary phytochemical isolated from the Piper species, has been used as a natural medicine for pain, flu, and fever in ancient China and India. Although the health benefits of piperine have been widely studied, research on its effect on aging is limited. This study aimed to determine whether piperine has the potential to mitigate aging-related changes in the fruit fly (Drosophila melanogaster), which is an excellent model organism for studies on aging. The experiments were conducted using the newly eclosed or 30-day-old D. melanogaster wild-type strain Cantonized-white. Piperine was dissolved in 99% ethanol and added to the sucrose-yeast medium at a final concentration of 10, 35, 70, or 100 µM. The study examined the effects of piperine supplementation on the lifespan of D. melanogaster and other physiological functions, such as fecundity, feeding, lipid content, and resistance to environmental stress. Log-rank tests, Shapiro-wilk test, F-test, t-test, or Wilcoxon rank sum test were used to analyze the data. Piperine failed to change the lifespan and body weight, but increased the fecundity and decreased the feeding rate in one-week-old flies. However, when piperine was fed to 30-day-old flies, it increased the lifespan of male flies and the fecundity and feeding rate of female flies. These results indicate that piperine can improve the health of aged flies. The findings suggest that piperine has age-dependent and sex-specific anti-aging effects in fruit flies.
Publisher
Research Square Platform LLC
Reference47 articles.
1. Evaluation of the effect of piperine per se on blood glucose level in alloxan-induced diabetic mice;Atal S;Acta Pol Pharm,2012
2. Multitrait evolution in lines of Drosophila melanogaster selected for increased starvation resistance: the role of metabolic rate and implications for the evolution of longevity;Baldal EA;Evolution,2006
3. A systemic review on the antioxidant and anti-inflammatory effects of resveratrol, curcumin, and dietary nitric oxide supplementation on human cardiovascular health;Banez MJ;Nutr Res,2020
4. Piperine suppresses growth and migration of human breast cancer cells through attenuation of Rac1 expression;Buranrat B;Asian Pacific Journal of Tropical Medicine,2022
5. Piperine reverses high fat diet-induced hepatic steatosis and insulin resistance in mice;Choi S;Food Chem,2013
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