Assessment of Retinal and Choroidal Vessel Density and Nerve Fiber Layer Thickness Changes After Orbitotomy in Sever NON- Active Thyroid Orbitopathy Patients (A Retrospective Study)

Abstract

Abstract Purpose: Evaluation the optical coherence tomography angiogram changes in non-active sever thyroid related ophthalmopathy patients after cosmetic bone decompression Methods: included 18 patients (25 eyes) with severe not active not compressive (NANC) TED who were candidates for decompression surgery for cosmetic reasons and A 3 × 3 mm macular scan was used to measure vessel density and RNFL thickness. Whole macular vessel density, in its superficial, deep and choriocapillaris layers were evaluated. Whole macular vessel density, in its superficial, deep and choriocapillaris layers were evaluated. The following data was extracted for each of layers: superior and inferior hemispheres, fovea, parafoveal vessel density, its superior and inferior hemispheres, and temporal, superior, nasal, and inferior quadrant. Results: The mean RPC increased postoperatively, which was statistically significant in small vessels of peripapillary area. (p-value=0.045).The mean RNFL thickness decreased after surgery and it was statistically significant in the peripapillary (p-value= 0.032) and -Inferior-Hemifield area (p-value= 0.036). The choriocapillaris changes were significant in Superior-Hemifield (p-value= 0.031) and Fovea (p-value= 0.03). Conclusion: thyroid associated orbitopathy patients have a tendency to decrease vascular density and correlated with disease activity more than stage of orbitopathy. There was not a strong an even discrepant results in linkage of RNFL thickness and other optic nerve function tests and TED patients status and it is needed to do studies with more epidemiologic power and same methodology of study to be more comparable.