Abstract
Abstract
Background:The TMPRSS2 and ERG which could form the TMPRSS2-ERG gene fusion are two important genes in prostate cancer cells.Previous works by others have found that the ERG could interrupt androgen receptor (AR) signal transducting pathway and the TMPRSS2-ERG gene fusion acts in a pivotal role in prostate cancer progression.Results: In this study, through transfecting with wild-type androgen receptor with an androgen receptor negative prostate cancer cell line(PC3), both the androgen receptor(AR) ChIP-Seq and ChIP-chip data are generated for the androgen receoptor in the advanced PC3-AR cells. After a series of bioinformatics data analysis, it is found that TMPRSS2 and ERG genes are androgen receptor targeted putative highly significant genes in androgen receptor ChIP-Seq and ChIP-chip datasets in PC3-AR cells.Conclusions: Identifying of TMPRSS2 and ERG as androgen receptor targeted putative highly significant genes in advanced PC3-AR cells could serve the international scientific community for biomarker identifications and developing novel prostate cancer therapeutic strategies.
Publisher
Research Square Platform LLC
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