Identification of TMPRSS2 and ERG as androgen receptor targeted putative highly significant genes in PC3-AR cells from AR ChIP-Seq and ChIP-chip data

Author:

Hong Xu1

Affiliation:

1. Zhejiang University

Abstract

Abstract Background:The TMPRSS2 and ERG which could form the TMPRSS2-ERG gene fusion are two important genes in prostate cancer cells.Previous works by others have found that the ERG could interrupt androgen receptor (AR) signal transducting pathway and the TMPRSS2-ERG gene fusion acts in a pivotal role in prostate cancer progression.Results: In this study, through transfecting with wild-type androgen receptor with an androgen receptor negative prostate cancer cell line(PC3), both the androgen receptor(AR) ChIP-Seq and ChIP-chip data are generated for the androgen receoptor in the advanced PC3-AR cells. After a series of bioinformatics data analysis, it is found that TMPRSS2 and ERG genes are androgen receptor targeted putative highly significant genes in androgen receptor ChIP-Seq and ChIP-chip datasets in PC3-AR cells.Conclusions: Identifying of TMPRSS2 and ERG as androgen receptor targeted putative highly significant genes in advanced PC3-AR cells could serve the international scientific community for biomarker identifications and developing novel prostate cancer therapeutic strategies.

Publisher

Research Square Platform LLC

Reference47 articles.

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3. Confirmation of the high frequency of the TMPRSS2/ERG fusion gene in prostate cancer;Soller MJ;Genes Chromosomes Cancer,2006

4. Tomlins SA, et al (2008) Role of the TMPRSS2-ERG gene fusion in prostate cancer, Neoplasia, 10, 177–188. Tomlins SA, et al (2005) Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer, Science, 310, 644–648. Wang J, et al. (2008) Pleiotropic biological activities of alternatively spliced TMPRSS2/ERG fusion gene transcripts, Cancer research, 68, 8516–8524.

5. Three-color FISH analysis of TMPRSS2/ERG fusions in prostate cancer indicates that genomic microdeletion of chromosome 21 is associated with rearrangement;Yoshimoto M;Neoplasia,2006

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