Chaperonin Containing TCP-1 subunit 6A (CCT6A) is involved in development of colon cancer

Abstract

Abstract Purpose Worldwide, colon cancer (CC) is one of the most commonly occurring malignancies. However, the molecular basis of the pathogenesis of CRC needs to be further explored. Studies have demonstrated that the chaperonin-containing TCP1 (CCT) complex contributes to the development and progression of various tumors. However, the functional significance of CCT in CC is unclear. Methods This study explored the potential functions of CCT family genes in CC by bioinformatics analysis. In addition, we established a risk score model based on the CCT family genes, which was validated to effectively predict the prognosis of CC patients. Results We found that CCTA6, one of the CCT family genes, was significantly more highly expressed in CC tissues than in normal tissues, and that increased expression of CCT6A was associated with a lower survival rate in CC patients. These findings were validated by real-world data. Conclusion Through the preliminary exploration of the role of CCT family genes in CC in this study, we found that CCT6A may contribute significantly in CC, and thus this gene may be an attractive therapeutic target for CC patients.