Affiliation:
1. Pfizer Hellas
2. 2nd Orthopedic Clinic KAT General Hospital
3. 5th Orthopedic Clinic Asklepion Hospital
4. National and Kapodistrian University of Athens
5. 6th Orthopedic Clinic Asklepion Hospital
6. 3rd Orthopedic Dep. for Sports Injuries and Regenerative Medicine, Mitera General Hospital
7. 6th Orthopedic Clinic Hygeia Hospital
8. 1st Orthopedic Clinic Mitera Hospital
9. Naval Hospital Athens
10. Attikon University Hospital
Abstract
Abstract
Background
Osteoarthritis (OA) represents a leading cause of disability in the general population, with limited data available from the Greek OA patients.
Objectives
To evaluate the impact of moderate to severe symptomatic hip/knee OA that is resistant to, cannot tolerate, or is ineligible for paracetamol and/or NSAIDs and/or opioids.
Methods
A non-interventional, cross-sectional, prospective, epidemiological analysis of data from the medical records of patients with moderate to severe OA, recruited in a single visit from 9 sites in Greece. Outcomes included patients’ demographic and clinical characteristics, as well as patient reported outcome measures: the Hip disability and Osteoarthritis Outcome Score (HOOS), the Knee Injury and Osteoarthritis Outcome Score (KOOS) and the EuroQol-5-Dimensions 3-levels questionnaire (EQ-5D-3L).
Results
A total of 164 patients were included in the analysis. The majority of participants were females (78.7%), and the mean (SD) age was 70.5 (10.2) years. Presence of comorbidities was reported by 87.2% of patients, with hypertension being the most frequently reported (53.7%), followed by dyslipidemia (31.1%), obesity (24.4%) and diabetes mellitus (23.2%). Paracetamol was the most commonly used analgesic treatment (96%), followed by NSAIDs (systemic) (75%), opioids (50%) and locally applied medications (42.7%). Both hip and knee OA patients showed substantial deterioration in health related QoL and health status as reflected by the HOOS/KOOS (most impaired subscale Function in sport and recreation, followed by Hip- or Knee-related QoL), mean (SD) EQ-5D-3L index score of 0.396 (0.319) and a mean (SE) EQ-VAS score of 52.1 (1.9), respectively.
Conclusion
Our findings confirmed the functional disability and impaired QoL of Greek patients with moderate to severe hip/knee OA, thus emphasizing the need for appropriate intervention to reduce the overall burden of the disease both on patients and on the society.
Publisher
Research Square Platform LLC